Safety and Tolerability of OROS Methylphenidate for the Treatment of ADHD

We review the effect of methylphenidate, focusing on Osmotic-controlled Release Oral delivery System (OROS) methylphenidate, on cardiovascular system, appetite and growth, sleep, tic, epilepsy, psychiatric and rare adverse events. Although OROS methylphenidate has side effects including increased heart rate or blood pressure, decreased appetite, delayed sleep onset, emergence or aggravation of tics, withdrawal or changes in mood, these effects appeared to be minimal in impact or difficult to distinguish from risk to untreated population and tended to be improved by dose adjustment or drug discontinuation. However, in subjects with underlying cardiac problems, uncontrolled epilepsy, previous psychotic episode, clinicians should pay attention and balance the risk and benefit.

Safety and Tolerability of OROS Methylphenidate for the Treatment of ADHD

We review the effect of methylphenidate, focusing on Osmotic-controlled Release Oral delivery System (OROS) methylphenidate, on cardiovascular system, appetite and growth, sleep, tic, epilepsy, psychiatric and rare adverse events. Although OROS methylphenidate has side effects including increased heart rate or blood pressure, decreased appetite, delayed sleep onset, emergence or aggravation of tics, withdrawal or changes in mood, these effects appeared to be minimal in impact or difficult to distinguish from risk to untreated population and tended to be improved by dose adjustment or drug discontinuation. However, in subjects with underlying cardiac problems, uncontrolled epilepsy, previous psychotic episode, clinicians should pay attention and balance the risk and benefit.

Insecure Attachment and Impulsivity-Inattention Problem in Adolescent with a High Risk of Substance or Internet Addiction / 신경정신의학

OBJECTIVES: This study was done in adolescents with a high risk of substance or internet addiction in order to confirm the assumption that insecure attachment formation and impulsivity-inattention problems are major risk factors in adolescent addictive behavior. METHODS: 2,188 middle and high school students including a nicotine dependent treatment group were assessed using self-reporting scales : Adolescent Drinking Index (ADI), Fagerstrom Tolerance Questionnaire, Young Internet Addiction Scale, Revised Adult Attachment Scale (RAAS), and the Conner and Well's Self-reporting Scale for ADHD (CASS) were used. Subjects were classified into risk groups including substance addiction, internet addiction, as well as a combined group. RESULTS: Significant correlations were found between attachment formation and internet addiction tendencies, with respect to dependence, anxiety, and closeness (r=-0.185, r=0.248, r=-0.147, p<0.01, respectively). Impulsivity-inattention problems had positive correlations with internet addiction, alcohol addiction and nicotine addiction groups (r=0.345, r=0.211, r=0.187, p<0.01). With regard to attachment formation, the four groups showed significant differences regarding dependence (F=19.427, p<0.01), anxiety (F=28.926, p<0.01), and closeness (F=12.853, p<0.01). In addition, the four groups showed significant difference with respect to impulsivity-inattention problems (F=83.857, p<0.01), of which the combined risk group showed the highest scores, and the non-addicted group had the lowest scores. CONCLUSION: Insecure attachment formation and impulsivity-inattention problems were major risk factors for adolescent addictive behavior including internet addiction.

The Effect of Temperament and Attachment Type on Adolescent Test Anxiety / 신경정신의학

OBJECTIVES: Through mass survey with Seoul School Health Center, this study was performed to find out any correlational factors that affect test anxiety in individual's temperament and attachment type among middle and high school students in Seoul. METHODS: Subjects were 4,178 students from 6 middle schools, 5 high schools and 1 technical high school in this study from May to June, 2005. Test Anxiety Inventory (TAI) by Spielberger, Revised Adult Attachment Scale (RAAS) by Collins and Read and Junior Temperament Character Inventory (JTCI) by Ludy were used in this study. RESULTS: Among 4 groups by sex and age, high school girls had the highest level of test anxiety and high school boys had the lowest level of test anxiety. The attachment subscore showed no significant differences in four groups. High school girls had higher social susceptibility but had lower novelty seeking subscores than high school boys. Middle school students revealed no meaningful differences of temperament between sex. Compared to low test anxiety group, high test anxiety group showed significantly high anxiety subscores in attachment scale and high harm avoidance subscores in temperament scale. However, the results of other three subscores of temperament and two subscores of attachment were reversed. Anxiety subscore of attachment and harm avoidance subscore of temperament positively correlated with test anxiety score (r=0.26, r=0.32). However, other subscores negatively correlated with test anxiety score and the correlation coefficient scores were very low. CONCLUSION: We concluded that, in temperament and attachment aspect, the most important factor affecting test anxiety was harm avoidance temperament and the next important factor was anxious attachment.